Cullin-RING ubiquitin ligase regulatory circuits: a quarter century beyond the F-box hypothesis
JW Harper, BA Schulman - Annual review of biochemistry, 2021 - annualreviews.org
… CUL1) and the E2 ubiquitin conjugating enzyme Cdc34, and (c) … of the assembly, the hallmark
E3 ligase RING domain does … and activates a partner ubiquitin-carrying enzyme (22–28). …
E3 ligase RING domain does … and activates a partner ubiquitin-carrying enzyme (22–28). …
The E2 ubiquitin-conjugating enzyme UbcH5c: An emerging target in cancer and immune disorders
… -activating enzyme (E1), the ubiquitin-conjugating enzyme (E2), and the ubiquitin ligase (E3)
1, 2. E1 initially binds and … ROC1 directly interacts with UbcH5c and promotes the transfer of …
1, 2. E1 initially binds and … ROC1 directly interacts with UbcH5c and promotes the transfer of …
Exploiting the SCF complex to identify novel therapeutic targets in high-grade serous ovarian cancer
A Farrell - 2023 - mspace.lib.umanitoba.ca
… the E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligase) enzymes17,…
substrate binding site, a C-terminal cullin-homology domain that interacts with its respective …
substrate binding site, a C-terminal cullin-homology domain that interacts with its respective …
Cryo-EM structure of CUL5-ARIH2 E3-E3 ligase complex reveals novel allosteric NEDD8 mechanism
S Kostrhon - 2022 - mediatum.ub.tum.de
… into an E3-E3 ubiquitin ligase complex with HIV-1 Vif-… for different cullins and allow for a
rapid assembly of new active CRL … Neddylation activates fully assembled CRLs and leads to …
rapid assembly of new active CRL … Neddylation activates fully assembled CRLs and leads to …
Proteolysis-dependent regulation of telomerase
D Degtev - 2021 - era.ed.ac.uk
… rely on a single ubiquitin-conjugating enzyme, whereas some … All ubiquitin ligases fall
into two major classes: the RING-… Cullin acts as a scaffold for the complex assembly. The C-…
into two major classes: the RING-… Cullin acts as a scaffold for the complex assembly. The C-…
BLF1-Mode of Action in Barley Leaf Size Control
O Soltani - 2023 - publishup.uni-potsdam.de
… ), ubiquitin-conjugating enzyme (E2), and ubiquitin … , RING-type E3s can also exist in
multi-subunit assemblies. One of the well characterized examples for this is the Cullin RING Ligase (…
multi-subunit assemblies. One of the well characterized examples for this is the Cullin RING Ligase (…